Studies on the kinetics of marrow regeneration after local irradiation of the femur in rabbits.
نویسندگان
چکیده
The development of 2 laboratory technics for more accurate quantification of hematopoietic activity, (a) radioactive iron (SgFe) uptake and (b) DNA content of marrow cells, are described, utilizing a regenerating marrow system in rabbits after local irradiation of 1 femur while shielding the contralateral leg. The sensitivity and reproducibility of the 2 methods were determined; there was good correlation of the results obtained with these 2 technics. The significance of these tests of bone marrow activity as useful indicators in the experimental evaluation of new myelosuppressive agents is discussed.
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ورودعنوان ژورنال:
- Cancer research
دوره 28 2 شماره
صفحات -
تاریخ انتشار 1968